Fig. 2.

Potential mechanisms leading to tau hyperphosphorylation in Huntington’s disease. Since mutant huntingtin does not directly interact with tau, several hypotheses have been explored to explain the tau hyperphosphorylation seen in HD, including an interaction between the mutant huntingtin and tau kinases/phosphatases, and an interaction between mutant huntingtin and proteins involved in tau alternative splicing (FUS, SRSF6).