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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: J Control Release. 2022 Jul 14;349:413–424. doi: 10.1016/j.jconrel.2022.07.008

Fig. 2. PLN-formulated ICLs extravasate glioma tumors more efficiently than liposomal ICLs.

Fig. 2.

PLNs or liposomes were injected i.v. (0.14 μmol DiD/kg); A) Circulation half-life of PLN or liposomal DiD (n=3 mice); B) representative confocal images (from 3 mice per group) of fresh tumor slices at 1h post-injection of liposomal and PLN-formulated DiD (mice were perfused postmortem to remove the blood); C) line profiles drawn across representative blood vessels show much more efficient spreading of PLN-formulated DiD than liposomal DiD; D) quantification of fluorescence-positive areas (top) and extravascular fluorescence areas (bottom) in fresh tumor slices of PLN DiD-injected mice (N=3 mice per group, 2-tailed parametric t-test). P-value: ****<0.0001.