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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: J Control Release. 2022 Jul 14;349:413–424. doi: 10.1016/j.jconrel.2022.07.008

Fig. 4. PLN-formulated ICLs extravasate and accumulate in gliomas more efficiently than 70kDa rhodamine-dextran.

Fig. 4.

GL261 tumor-bearing mice were co-injected with DiD PLN and rhodamine dextran (0.14 and 0.33 μmol dye/kg, respectively). A) Representative confocal images of different areas of fresh non-fixed GL261 tumor slices show superior extravasation of PLN-formulated DiD over dextran injected in the same mice; B) quantification of % tumor fluorescent area (n=3 mice per group, pairwise t-test. P-value: ****<0.0001); C-D) minimal accumulation of rhodamine dextran at 48h injected in a separate cohort of GL261 tumor-bearing mice (n=3 mice per group).