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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: J Control Release. 2022 Jul 14;349:413–424. doi: 10.1016/j.jconrel.2022.07.008

Fig. 8. PLNs show instability in serum in vitro and in vivo.

Fig. 8.

A) Normalized FRET efficiency (Supplemental Fig. 9 for absolute FRET values) after incubation of double-labeled PLNs and liposomes in mouse serum; B) confocal microscopy in plasma post-injection shows the disintegration of PLNs and stability of liposomes. The size bar is the same for all images; C) high magnification microscopy of GL261 tumor histological sections show a separation of PLN-formulated DiI/DiD, but not liposomal DiI/DiD at early steps of tumor entry; D) colocalization of DiI and DiD in PLN injected tumors and in liposome-injected tumors (Pearson coefficient, calculated with Coloc2 in Fiji).