Table 2.
Language and socioemotional profile
| Right temporal | Frontal | Left temporal | Healthy control | |
|---|---|---|---|---|
| Language | ||||
| Verbal Agility, EMM (SE, n), max = 5 | 4.94 (0.19, 36) | 4.73 (0.16, 54)a | 5.00 (0.16, 57)a | 5.00 (0.19, 52) |
| Repetition, EMM (SE, n), max = 5 | 4.16 (0.19, 36)b | 3.84 (0.16, 57)c | 3.46 (1.52, 57)d | 4.43 (0.19, 59)b,c,d |
| WRAT Reading, EMM (SE, n), max = 70 | 56.64 (3.02, 21)e | 54.71 (2.18, 41)c | 50.00 (2.26, 38)d | 65.22 (2.11, 58)e,c,d |
| Apraxia of speech rating, EMM (SE, n), max = 7 | 0 (0.00, 27) | 0.14 (0.08, 14) | 0.06 (0.04, 49) | 0.0 (0.00, 9) |
| Dysarthria rating, EMM (SE, n), max = 7 | 0.09 (0.04, 43)f | 1.3 (0.09, 40)a,b,c | 0.06 (0.04, 50)a | 0.14 (0.07, 59)c |
| Syntax comprehension, EMM (SE, n), max = 5 | 4.43 (0.14, 36) | 3.97 (0.12, 56)a | 4.48 (0.12, 56)a | 4.38 (0.14, 52) |
| Lexical fluency—no. in 60 s, EMM (SE, n) | 8.53 (0.64, 43)e,f | 6.16 (0.61, 69)a,b,c | 8.51 (0.53, 66)a,d | 14.09 (0.81, 35)c,d,e |
| Verbal semantics | ||||
| BNT, EMM (SE, n), max = 15 | 6.89 (0.43, 33)e,f,b | 12.02 (0.35, 70)a,b | 5.18 (0.36, 66)a,b,d | 12.99 (0.46, 57)e,d |
| Verbal fluency—semantic—no. in 60 s, EMM (SE, n) | 9.21 (0.76, 43)e | 10.78 (0.74, 69)c | 8.99 (0.64, 66)d | 21.62 (0.78, 35)e,f,d |
| PPVT, EMM (SE, n), max = 16 | 9.56 (0.43, 40)e,f | 13.62 (0.45, 65)a,f | 9.53 (0.39, 53)d,f | 13.97 (0.46, 53)e,d |
| Pyramids and Palm Trees Percent, Pictures, EMM (SE, n), max = 1 | 0.81 (0.02, 27)e,f | 0.90 (0.01, 49)f | 0.86 (0.01, 53) | 0.90 (0.01, 30)e |
| Face perception | ||||
| CATS Face Matching, EMM (SE, n), max = 12 | 11.24 (0.20, 31) | 10.66 (0.18, 42)a,f | 11.79 (0.17, 41)a | 11.55 (0.18, 52)c |
| Person-specific knowledge | ||||
| Famous Faces Naming, EMM (SE, n), max = 20 | 1.26 (0.86, 15)e,f | 6.88 (1.19, 9)a,c,f | 1.75 (1.00, 17)a,d | 12.82 (0.87, 26)c,d,e |
| Famous Faces Familiarity, EMM (SEM, n), max = 20 | 6.85 (0.88, 24)b,e,f | 17.48 (1.70, 7)f | 14.80 (0.92, 32)b | 14.19 (1.10, 26)e |
| Famous Faces Semantic Association, EMM (SE, n), max = 20 | 5.37 (1.13, 12)b,e,f | 16.19 (1.2, 8)a,f | 11.75 (1.37, 10)a,b | 14.71 (0.96, 26)e |
| Famous Faces Name Familiarity, EMM (SE, n), max = 16 | 2.80 (0.78, 14) | 9.80 (1.06, 10) | 2.92 (0.78, 10) | 11.91 (0.94, 29) |
| Social function and emotion | ||||
| CATS Affect Matching, EMM (SE, n), max = 16 | 9.11 (0.42, 35)b,e | 9.67 (0.39, 43)a,c | 12.82 (0.41, 40)a,b | 12.82 (0.46, 52)c,e |
| TASIT–EET, EMM (SE, n), max = 14 | 6.46 (0.48, 27)e | 7.77 (0.40, 45)c | 8.19 (0.42, 40)d | 10.89 (0.40, 57)c,e,f |
| TASIT SI-M Sincere, EMM (SE, n), max = 20 | 15.99 (0.69, 24)f | 13.42 (0.52, 51)a,c,f | 17.16 (0.55, 42)a | 16.64 (0.55, 58)c |
| TASIT SI-M Sarcastic, EMM (SE, n), max = 20 | 4.74 (0.85, 24)b,e,f | 13.49 (0.65, 51)a,c,f | 9.80 (0.67, 42)a,b,d | 17.60 (0.68, 58)e, |
| IRI-Empathetic Concern, EMM (SE, n), max = 24 | 16.09 (1.41, 44)b,e | 14.94 (1.12, 79)a,c | 21.87 (1.14, 75)a,b,d | 27.41 (1.56, 54)c,d,e |
| IRI Perspective Taking, EMM (SE, n), max = 24 | 10.77 (1.10, 44)b,e | 10.22 (0.87, 79)a,c | 14.63 (0.89, 75)a,b,d | 22.86 (1.22, 54)c,d,e |
| Emotional Theory of Mind, EMM (SE, n), max = 16 | 12.25 (0.46, 9)e | 12.44 (0.29, 23)a,c | 13.86 (0.36, 17)a | 14.62 (0.35, 20)c,e |
| Cognitive Theory of Mind, EMM (SE, n), max =16 | 14.79 (0.58, 15)f | 12.04 (0.44, 30)a,c,f | 15.07 (0.44, 33)c | 15.07 (0.35, 59)a |
| Behavioural Inhibition BIS-Total, EMM (SE, n), max = 24 | 17.39 (0.73, 24) | 17.49 (0.55, 54)a | 19.85 (0.59, 41)a,d | 15.95 (0.61, 54)d |
| Behavioural Activation BAS-Drive, EMM (SE, n), max = 24 | 8.56 (0.56, 25) | 10.21 (0.42, 50) | 9.99 (0.44, 38) | 10.40 (0.47, 54) |
| Behavioural Activation BAS-Fun, EMM (SE, n), max = 24 | 7.54 (0.49, 25)e,f | 9.47 (0.39, 50)f | 8.69 (0.42, 36) | 9.50 (0.42, 53)e |
| Behavioural Activation BAS-Reward, EMM (SE, n), max = 24 | 13.13 (0.52, 25)b,e | 13.59 (0.42, 51)a | 15.69 (0.44, 38)a,b | 15.08 (0.45, 54)e |
| IAS—Current Warmth, EMM (SE, n) | 37.59 (3.02, 13)b,c | 38.86 (1.95, 36)a,c | 46.56 (1.84, 44)a,b | 47.89 (2.12, 44)e,f |
| IAS—Current Dominance, EMM (SE, n) | 37.24 (2.59, 13) | 30.86 (1.68, 36)a,c | 37.76 (1.58, 44)a | 42.21 (1.82, 44)c |
| IAS—Current Coldness, EMM (SE, n) | 29.53 (2.27, 13)b,c | 24.77 (1.71, 36)c | 18.88 (1.71, 44)b | 13.72 (1.83, 44)c,e |
| Self-Monitoring RSMS, EMM (SE, n), max = 65 | 36.57 (2.32, 28)b,c | 38.68 (1.78, 55)a,c | 45.14 (1.86, 49)a,b,d | 59.05 (2.24, 47)c,e,f |
| Depression GDS, EMM (SE, n), max = 30 | 7.56 (0.94, 37)e | 8.88 (0.87, 54)c | 8.54 (0.83, 50)d | 3.38 (0.92, 58)c,e,f |
A = Asian; BNT = Boston Naming Test; EC = Empathic Concern; EMM = estimated marginal means; GDS = Geriatric Depression Scale; IAS = Interpersonal Adjective Scales; IRI = Interpersonal Reactivity Index; N = Native American; PPVT = Peabody Picture Vocabulary Test; PT = Perspective Taking; SE = standard error; W = White.
a
Frontal different from left temporal at <0.05.
b
Right temporal different from left temporal at <0.05.
c
Frontal different from health control at <0.05.
d
Left temporal different from health control at <0.05.
e
Right temporal different from health control at <0.05.
f
Right temporal different from frontal at <0.05.