Table 3.
Factors Associated With FAST Score >0.35 Among Women With Human Immunodeficiency Virus (n = 928)
| Factor | Unadjusted | Adjusteda | ||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Age (per 10 y) | 1.26 (.89–1.78) | .19 | 1.45 (1.00–2.10) | .048 |
| Race/ethnicity (ref = white) | ||||
| Black | .56 (.29–1.07) | .08 | .43 (.20–.93) | .03 |
| Other | 1.08 (.43–2.73) | .87 | 1.29 (.46–3.65) | .63 |
| Hispanic | 1.43 (.68–3.00) | .34 | .86 (.33–2.29) | .77 |
| Waist circumference (per 10 cm) | 1.56 (1.32–1.85) | <.001 | 1.62 (1.32–1.98) | <.001 |
| BMI (per 5 kg/m2)b | 1.33 (1.17–1.53) | <.001 | … | |
| HOMA-IR (per doubling) | 1.43 (1.17–1.73) | <.001 | 1.08 (.84–1.39) | .55 |
| Diabetes mellitus (ref = no)c | 2.76 (1.58–4.83) | <.001 | … | |
| On HTN medication (ref = no) | 1.36 (.77–2.23) | .33 | … | |
| On antidepressant medication (ref = no) | 1.38 (.78–2.44) | .27 | … | |
| Alcohol use (ref = none) | ||||
| Light | 1.20 (.69–2.10) | .52 | 1.29 (.71–2.33) | .41 |
| Moderate | 1.16 (.26–5.11) | .85 | 1.02 (.21–4.88) | .98 |
| Heavy | .95 (.28–3.25) | .94 | 1.14 (.31–4.18) | .85 |
| Current smoking | 1.35 (.79–2.31) | .28 | … | |
| Current marijuana use | .53 (.23–1.18) | .12 | … | |
| Ever injection drug use | 1.38 (.32–6.00) | .67 | … | |
| Undetectable HIV viral load | .53 (.31–.91) | .02 | .40 (.22–.72) | .002 |
| CD4 current (per 100 cells/µL) | .96 (.88–1.04) | .28 | … | |
| CD4 nadir (per 100 cells/µL) | .95 (.82–1.10) | .50 | … | |
| PI (ref = non-PI ART) | .32 (.13–.81) | .01 | .34 (.14–.82) | .02 |
Abbreviations: ART, antiretroviral therapy; BMI, body mass index; CI, confidence interval; FAST, FibroScan–aspartate aminotransferase; HIV, human immunodeficiency virus; HOMA-IR, homeostatic model assessment of insulin resistance; HTN, hypertension; OR, odds ratio; PI, protease inhibitor.
Adjusted for covariates included in table.
Not included in final adjusted model due to collinearity with waist circumference. When replaced with waist circumference in the adjusted model, the OR was 1.34 (95% CI, 1.14–1.57), P < .001.
Not included in final adjusted model due to collinearity with HOMA-IR. When replaced with HOMA-IR in the adjusted model, the OR was 1.71 (95% CI, .91–3.22), P = .09.