Table 3.
Factors associated with pediatric clinical trial reporting of participant socioeconomic factors
| Trial Characteristics | Reported Socioeconomic Factors (N=293), n (%) |
Did Not Report Socioeconomic Factors (N=319), n (%) |
Adjusted Odds Ratio (95% CI) |
P value |
|---|---|---|---|---|
| Participant age group in article | ||||
| All pediatric age groups | 39 (13.3) | 52 (16.3) | 0.81 (0.39, 1.66) | 0.56 |
| Neonate (0-30 days) | 31 (10.6) | 84 (26.3) | Referent | |
| Infants and toddlers (31 days-3 years) | 55 (18.8) | 37 (11.6) | 2.04 (1.04, 4.06) | 0.04 |
| Pre-school and school age (4-12 years) | 77 (26.3) | 61 (19.1) | 1.07 (0.56, 2.06) | 0.83 |
| Adolescent (13-18 years) | 91 (31.1) | 85 (26.6) | 0.57 (0.29, 1.11) | 0.10 |
| Trial allocation | ||||
| Not randomized | 9 (3.1) | 29 (9.1) | Referent | |
| Randomized | 284 (96.9) | 290 (90.9) | 2.29 (0.90, 6.37) | 0.10 |
| Trial enrollment | ||||
| <100 | 45 (15.4) | 127 (39.8) | Referent | |
| 100-499 | 149 (50.9) | 135 (42.3) | 2.05 (1.26, 3.35) | 0.004 |
| ≥500 | 99 (33.8) | 57 (17.9) | 2.02 (1.15, 3.56) | 0.01 |
| Trial intervention | ||||
| Drug/biologic/dietary supplement | 57 (19.5) | 182 (57.1) | Referent | |
| Behavioral | 171 (58.4) | 73 (22.9) | 8.48 (5.22, 14.11) | <0.001 |
| Device/procedure | 19 (6.5) | 56 (17.6) | 1.00 (0.52, 1.87) | 0.99 |
| Screening/Referral or Health services | 46 (15.7) | 8 (2.5) | 18.16 (7.86, 47.07) | <0.001 |
| Funding source | ||||
| Public and Private | 68 (23.2) | 60 (18.8) | Referent | |
| Private | 36 (12.3) | 76 (23.8) | 0.39 (0.21, 0.72) | 0.003 |
| Public | 186 (63.5) | 156 (48.9) | 0.89 (0.54, 1.45) | 0.63 |
| None Reported | 3 (1.0) | 27 (8.5) | 0.20 (0.04, 0.68) | 0.02 |
Note: Boldface indicates statistical significance (P<0.05).