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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Gastroenterology. 2023 Feb 4;164(7):1119–1136.e12. doi: 10.1053/j.gastro.2023.01.037

Figure 7. Elevated expression of SOX9 is associated with gastric cancer recurrence and poor prognosis.

Figure 7.

(A) Representative images of SOX9 IHC staining in the normal human stomach. (B) Using TCGA and GEO database to examine the expression of SOX9 in gastric cancer and adjacent normal tissues. (C) Representative images of different score of SOX9 IHC staining in gastric cancer tissues. (D) Association of SOX9 expression, tumor location and stage in gastric cancer cohorts. (E) Association of SOX9 expression and the frequency of various recurrence patterns. (F) Kaplan-Meier analyses of the correlations between SOX9 expression and the overall survival or disease-free survival in 244 patients. (G) Univariate and multivariate survival Cox regression analyses for the 244 patients with gastric cancer. (H) Effect of chemotherapy on the overall survival and disease-free survival in gastric cancer patients with low and high SOX9 expression. ACT, adjuvant chemotherapy. Data are expressed as mean ± SD. Statistical analyses used unpaired t-test. *p < 0.05; **p < 0.01; ***p < 0.001; n.s. no significance. Scale bar in A, 200 μm; C, 100 μm.