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. 2023 May 12;27:560–573. doi: 10.1016/j.bioactmat.2023.04.010

Fig. 2.

Fig. 2

Responsive behaviors of MnCO3@Te improve ROS generation through fenton-like reaction and realizes efficient MR imaging and ultrasonic imaging in vitro. (a) Schematic illustration reflecting the MnCO3@Te heteronanostructures and its bioresponsibility in TME. (b) TEM image of MnCO3 and MnCO3@Te after incubation in PBS solution with different pH values for different times. (c–d) Release behaviors of Mn2+ from MnCO3@Te in pH 7.4 and 5.0 environment within 72 h. (e) The absorbance spectra of MB solutions containing MnCO3@Te at different time periods under X-Ray radiation for detection of •OH. (f–g) With/without X-Ray irradiation, the degradation curves of MB probes at 655 nm after incubation under various treatments. (h) ESR spectra of detection of •OH of MnCO3@Te immersed in H2O2 solution under X-Ray irradiation. (i) Intracellular ROS levels in MDA-MB-M231 cells, determined by DHE probe. (j) Representative fluorescence images of ROS level in MDA-MB-M231 cells after different treatments. T1-weighted MR imaging (k) and T1 relaxation rates (l) of MnCO3@Te with different concentrations after incubation with different conditions. (m–n) Ultrasound imaging and statistical data of MnCO3@Te in acid buffer.