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. 2023 May 12;27:560–573. doi: 10.1016/j.bioactmat.2023.04.010

Fig. 4.

Fig. 4

Anticancer action mechanism of combination treatment of MnCO3@Te and X-Ray to MDA-MB-231 cells. (a–b) Cellular uptake of different concentrations MnCO3@Te for different time points, determined by flow cytometry. (c) Representative fluorescence images of DNA fragmentation of MDA-MB-231 cells treated with MnCO3@Te and X-ray radiation. (d) Representative images of mitochondrial dysfunction caused by MnCO3@Te and X-ray radiation. (e–f) JC-1 assay for illustrating the depletion of mitochondrial membrane potential in MDA-MB-231 cells treated with MnCO3@Te and then X-Ray irradiation. (g–h) Flow cytometric analysis of the cell cycle of MDA-MB-231 cells after introduction MnCO3@Te with or without X-rays (2 Gy). (i) Annexin V-FITC/PI staining kit detected the apoptosis of MDA-MB-231 cells treated with MnCO3@Te followed by X-Ray exposure.