Fig. 6.

Anticancer immunity of MnCO₃@Te-mediated radiotherapy in combination of anti-PD-L1 in vivo. (a) Schematic illustration showing the experiment design using MnCO₃@Te-based RT and anti-PD-L1 to treat mice bearing 4T1 tumors. (b) Average tumor weight of various groups after treatment. (c) Photographs of tumors excised from Balb-c mice. (d) Relative tumor growth curves in different treatment groups. (e) Growth curves of tumor volume for individual Balb-c mice following various treatments. (f) Mice weight changes within treatment period. (g) H&E-stained images of tumor tissues collected from mice post various treatments. Quantification analysis of the infiltration of T lymphocytes including CD8⁺CD3⁺ T cells (h) and CD3⁺CD4⁺ T cells (i) after various treatments. Quantification analysis of decline of intratumoral immunosuppressive cells including Treg cells (j) and MDSC cells (k) in tumor tissues. (l) Flow cytometry analysis of the proportion of M2-phenotype tumor associated macrophages within tumor tissues from different immunized mice.