Table 2.
A list of human lncRNAs induced in macrophages, localization, stimuli, and brief functions
| lncRNA | Localization | Stimuli | Functions | Ref. |
|---|---|---|---|---|
| PACER | Nucleus | LPS | Relates with suppressive p50- subunits to ease the production of COX-2. | 423 |
| THRIL | Nucleus | Pam3Csk4 | Regulates TNF-α activation and production by interacting with the TNFA promoter over a composite with hnRNPL. | 424 |
| MacORIS | Cytoplasm | LPS + IFN-γ | Suppresses IFN-γ activity by JAK2/STAT1 phosphorylation. | 425 |
| MALAT1 | Nucleus | LPS Lipid uptake | Interacts p65-p50 complex to avert NF-κB interaction to the promoter domains of NF-κB-triggered genes. Controls the transcription of CD36. | 426 |
| Lnc-MC | Cytoplasm | Macrophage differentiation | Binds with miR-199a-5p to suppress ACVR1B activity. | 427 |
| CircANRIL | Nucleus | Stimulates apoptosis following binding to PES1, damaging preRNA expression | 428 | |
| LincRNA-DYNLRB2–2 | Cholesterol loading | Leads atheroprotection over the regulation of GPR119 and ABCA1. | 429 | |
| RP5–833A20.1 | Nucleus | Cholesterol loading | Regulates cholesterol transportation with the help of NFIA and miR-382–5p. | 427 |
| NEAT1 | Nucleus | Cholesterol loading, Virus | Arbitrates the development of paraspeckles-resulting in multiple downstream responses. | 430 |
| IL1β-eRNA, IL1β-RBT46 | Nucleus | LPS | Controls the expression of IL-1β and CXCL8 as eRNA. | 431 |
| Linc00689 | Cytoplasm | TNFα | Codes for TNF-α-responsive micro peptide inside the HeLa cells. | 432 |
| LncRNA-ACOD1 | Cytoplasm | Viruses | Interacts right to GOT2, augmenting its function. | 433 |
| FIRRE | Nucleus | LPS | Alleviates inflammatory genes with the help of hnRNPU. | 433 |
| CARL/Carlr | Nucleus Cytoplasm | NF-κB | Enables the transportation of p65 leading from the cytoplasm to the nucleus. | 434 |
| H19 | Nucleus | oxLDL | Collaborates with miR-130b through foam cell establishment. | 435 |
| HcircRasGEF1B | Cytoplasm | LPS | Positively controls the permanence of ICAM-1 transcript and induction in the LPS/TLR4 signaling pathway | 436 |
| Lnc-BM | Cytoplasm | OSM | Stimulates BCBMs by arbitrating communication among breast cancer cells and the brain microenvironment | 437 |
| LncRNA-KCNQ1OT1 | Nucleus | PMMA | Prompts M2 macrophages polarization to enhance particle-induced osteolysis by preventing miR-21a-5p | 438 |
| lncRNA-ATB | Cytoplasm | TGF-β1 | LncRNA-ATB interacts with miR-200c to release ZEB1, instigating enhanced EMT development | 439 |
| FIRRE | Nucleus Cytoplasm | LPS | Relates with heterogeneous nuclear ribonucleoproteins U, controlling the permanence of mRNAs of particular inflammatory genes | 440 |