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. 2023 May 12;92:104596. doi: 10.1016/j.ebiom.2023.104596

Fig. 1.

Fig. 1

Expression analyses highlighted unique molecular characteristics of BHD-associated renal tumours. (a) Hematoxylin and eosin staining of renal tumours analyzed in this study. Images are shown at 400× magnification. Scale bars represent 50 μm. (b) Heatmap shows expression profiling of sixteen BHD-associated renal tumours, twenty-one sporadic ChRCC and seven sporadic oncocytomas. Sporadic ChRCC and sporadic oncocytomas was further clustered into two distinct subclusters; Group1(gFOXI1) and Group2 (gL1CAM); further analyses are done in Fig. 2 gL1CAM: group of sporadic ChRCCs with predominant expression of L1CAM. gFOXI1: group of sporadic ChRCCs with predominant expression of FOXI1. (c) Bar plot shows gene set enrichment analysis (GSEA) results comparing sixteen BHD-associated renal tumours and twenty-one sporadic ChRCCs (upper panel). Some of the GSEA enrichment plots are shown (lower panels).