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. 2023 May 8;14:1129657. doi: 10.3389/fendo.2023.1129657

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Copyright © 2023 Zhang, Yu, Mei, Liu, Shao, Sun, Lu, Hu and Gu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell expression analysis of monocytes in POI and HC. (A) UMAP plot showing five cell subclusters from the monocyte cells in POI and HC. (B) The proportion of each subclusters of monocytes in POI and HC, Red star indicates statistical significance. (C) The heatmap of top 10 marker genes in each subclusters of monocytes. (D) The DEGs of monocytes between POI and HC. (E, F). Dot plot of enriched KEGG terms of the down-regulated (E) and up-regulated genes (F, G) Violin plots for some marker genes in classical monocytes.