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. 2023 May 8;14:1127441. doi: 10.3389/fendo.2023.1127441

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Copyright © 2023 Cui, Yuan, Chen, Jiang, Guan, Zhu, Li, Liu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Difference in drug sensitivity between low and high-risk patients in train, test1, test2, and test3 cohorts. The box plot for the estimated IC50 of 12 different types of regularly used chemotherapy regimens conducted in (A–D), (A–D) for low-risk (blue) and high-risk patients (purple). The 17 types of chemotherapeutic agents are AUY922, CGP.60474, cisplatin, CMK, dasatinib, docetaxel, EHT.1864, FTI.277, imatinib, JNJ.26854165, LFM.A13, metformin, midostaurin, pazopanib, PLX4720, salubrinal, and thapsigargin. On top of each cluster, the corresponding p-values are shown, and the P< 0.05 denotes the significance level.