Table 3.
Correlations of GLS (%) with characteristics and hormonal parameters in acromegalic patients.
| Variable | Test | Baseline | SRL 3 months | SRL 6 months | After TSS | ||||
|---|---|---|---|---|---|---|---|---|---|
| test | p | test | p | test | p | test | p | ||
| Age (years) | r | 0.185 | 0.311 | n/a | n/a | n/a | |||
| Sex (males vs females) | U | 0.062 | 0.001 | 0.003 | 0.062 | ||||
| BMI (kg/m2) | r | 0.446 | 0.011 | n/a | n/a | n/a | |||
| Disease duration (years) | r | 0.210 | 0.248 | n/a | n/a | n/a | |||
| BSA (m2) | r | 0.411 | 0.019 | n/a | n/a | n/a | |||
| Arterial hypertension (yes vs no) | U | 0.281 | 0.129 | 0.068 | 0.944 | ||||
| Diabetes status (diabetes, no, prediabetes) | H | 0.612 | 0.847 | 0.363 | 0.796 | ||||
| Dyslipidemia (yes vs no) | U | 0.459 | 0.924 | 0.815 | 0.823 | ||||
| Carotid arteries (atherosclerosis vs normal) | U | 0.276 | 0.181 | 0.796 | 0.874 | ||||
| Fasting GH (ng/mL) | r | 0.051 | 0.782 | -0.035 | 0.859 | 0.290 | 0.294 | 0.015 | 0.948 |
| Nadir GH during 75g OGTT (ng/mL) | r | -0.041 | 0.826 | * | * | 0.009 | 0.971 | ||
| IGF-1 (ng/mL) | r | 0.002 | 0.993 | 0.056 | 0.777 | 0.423 | 0.117 | 0.568 | 0.007 |
| IGF-1 (x ULN) | r | 0.066 | 0.721 | 0.151 | 0.444 | 0.446 | 0.096 | 0.570 | 0.007 |
n/a – not applied for time-dependent variables, * - not measured, SRL, somatostatin receptor ligand; TSS, transsphenoidal surgery,
r – Pearson correlation coefficient, U – Mann-Whitney test, H – Kruskal-Wallis test. The bold values are statistically significant.