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Groups of 3 healthy beagles received a 30-minute intravenous infusion of F2Lipo-MP-LPS.
| Dose (microg/kg) |
Infusion time (min) |
Transitory hyperthermia/tremors |
Increased ALAT Or ASAT levels |
Increased PA levels |
Transitory Leukopenia |
|---|---|---|---|---|---|
| 3 | 30 | 1/3 | 0/3 | 1/3 | 3/3 |
| 6 | 30 | 2/3 | 0/3 | 1/3 | 3/3 |
| 10 | 30 | 1/3 | 0/3 | 1/3 | 3/3 |
Dose levels were increased weekly, with a starting dose of 3 μg/kg on day 1, 6 μg/kg on day 8 and 10 μg/kg on day 15. Bloods were drawn then 3, 6, 9 and 24 hours after infusion.
