Table 2.
Significantly enriched pathways common to PT-NASH and NT-NASH.
| Common dysregulated pathways in post-transplant and non-transplant NASH | ||||
|---|---|---|---|---|
| Term | Term ID | PT-NASH FDR | NT-NASH FDR | Top 5 Intersection Genes |
| GO:0062023 | collagen-containing extracellular matrix | 4.00E-03 | 3.50E-02 | DCN, SEMA3B, SERPINB1, MYOC, TIMP2 |
| GO:0043062 | extracellular structure organization | 2.70E-02 | 6.00E-03 | CFLAR, ST7, ITGAL, ITGA3, ITGA2B |
| GO:0030198 | extracellular matrix organization | 2.70E-02 | 6.00E-03 | CFLAR, ST7, ITGAL, ITGA3, ITGA2B |
| GO:0045229 | external encapsulating structure organization | 2.80E-02 | 6.00E-03 | CFLAR, ST7, ITGAL, ITGA3, ITGA2B |
| GO:0042060 | wound healing | 2.80E-02 | 1.10E-02 | ENPP4, CFLAR, TFPI, KDM1A, SLC4A1 |
| GO:0009611 | response to wounding | 2.90E-02 | 1.10E-02 | ENPP4, CFLAR, TFPI, KDM1A, SLC4A1 |
| WP : WP4172 | PI3K-Akt Signaling Pathway | 4.70E-02 | 9.00E-03 | BAD, ITGA3, ITGA2B, BRCA1, IGF1 |
| WP : WP3932 | Focal Adhesion-PI3K-Akt-mTOR signaling pathway | 4.70E-02 | 9.00E-03 | BAD, ITGA3, ITGA2B, BRCA1, IGF1 |
Pathways of post-transplant DEGs with 0.1 FDR and non-transplant DEGs with 0.01 FDR cut-offs are shown. Pathways were considered functionally related if at least 80% of DEGs in the pathways were common to both gene sets.