Table 3.
Significantly enriched pathways specific to PT-NASH. Post-transplant DEGs with 0.1 FDR cut-offs are shown.
| Dysregulated pathways specific to post-transplant NASH | |||
|---|---|---|---|
| Term | Term ID | PT-NASH FDR | Top 5 Genes |
| GO:0061043 | regulation of vascular wound healing | 5.00E-05 | ALOX5, SLC12A2, XBP1, SERPINE1, SMOC2 |
| GO:0061042 | vascular wound healing | 4.60E-04 | ADIPOR2, ALOX5, SLC12A2, MCAM, XBP1 |
| GO:0005539 | glycosaminoglycan binding | 4.60E-04 | CFH, AOC1, MPO, PAFAH1B1, PGLYRP1 |
| GO:0001832 | blastocyst growth | 8.90E-04 | IGF1, PALB2, GINS1, SALL4, NBN |
| GO:0060055 | angiogenesis involved in wound healing | 1.60E-03 | CX3CL1, ADIPOR2, ALOX5, SLC12A2, MCAM |
| GO:0031012 | extracellular matrix | 1.85E-03 | MMP25, ANOS1, DCN, SEMA3B, SERPINB1 |
| GO:0061041 | regulation of wound healing | 1.85E-03 | ENPP4, TFPI, ABCC8, TNFRSF12A, TBXA2R |
| GO:0030312 | external encapsulating structure | 1.85E-03 | MMP25, ANOS1, DCN, SEMA3B, SERPINB1 |
| GO:0031091 | platelet alpha granule | 7.13E-03 | ITGA2B, CD9, IGF1, HGF, ACTN1 |
| GO:1903034 | regulation of response to wounding | 7.13E-03 | ENPP4, TFPI, ABCC8, TNFRSF12A, TBXA2R |
| GO:0008201 | heparin binding | 7.13E-03 | CFH, AOC1, MPO, PAFAH1B1, TENM1 |
| GO:1903047 | mitotic cell cycle process | 7.13E-03 | MAD1L1, CDC27, PRKAR2B, KMT2E, FBXL3 |
| GO:1905462 | regulation of DNA duplex unwinding | 7.30E-03 | MNAT1, MCM2, SSBP1, POT1, TOP2A |
| GO:0007093 | mitotic cell cycle checkpoint signaling | 8.65E-03 | MAD1L1, ZNF207, BRCA1, MRE11, SPDL1 |
| GO:0001824 | blastocyst development | 9.27E-03 | PSMC4, IGF1, CUL3, PTPN18, NLE1 |
| GO:1901381 | positive regulation of potassium ion transmembrane transport | 9.50E-03 | ABCC8, KCNQ1, KCNH2, WNK1, GAL |
| GO:0043268 | positive regulation of potassium ion transport | 1.48E-02 | ABCC8, FHL1, KCNQ1, KCNH2, WNK1 |
| GO:0006260 | DNA replication | 2.00E-02 | RECQL, UPF1, LIG3, DBF4, PSMB1 |
| GO:0030048 | actin filament-based movement | 2.00E-02 | CACNA1G, CCDC88C, WAS, ATP1A2, VIM |
| GO:0061044 | negative regulation of vascular wound healing | 2.00E-02 | ALOX5, SLC12A2, SERPINE1, MIR200B, TAFA5 |
| GO:0000075 | cell cycle checkpoint signaling | 2.00E-02 | MAD1L1, CRY1, ZNF207, BRCA1, MRE11 |
| GO:0033044 | regulation of chromosome organization | 2.07E-02 | MAD1L1, KDM1A, CDC27, UPF1, KMT2E |
| WP:2446 | Retinoblastoma Gene in Cancer | 2.07E-02 | E2F2, ANLN, HLTF, SMC1A, MCM6 |
| GO:0034764 | positive regulation of transmembrane transport | 2.07E-02 | CFTR, CALCR, ABCC8, CACNG3, CX3CL1 |
| GO:0044770 | cell cycle phase transition | 2.10E-02 | MAD1L1, CDC27, UPF1, PRKAR2B, KMT2E |
| GO:0031093 | platelet alpha granule lumen | 2.10E-02 | IGF1, HGF, ACTN1, ACTN2, TGFB2 |
| GO:0045931 | positive regulation of mitotic cell cycle | 2.74E-02 | POLDIP2, CDC27, KMT2E, PAFAH1B1, CUL3 |
| GO:0051607 | defense response to virus | 2.74E-02 | TSPAN6, MAP3K14, RNF216, POLR3B, ZMYND11 |
| GO:0140546 | defense response to symbiont | 2.74E-02 | TSPAN6, MAP3K14, RNF216, POLR3B, ZMYND11 |
| GO:1901989 | positive regulation of cell cycle phase transition | 2.74E-02 | CDC27, KMT2E, PAF1, CUL3, ANAPC4 |
| REAC:R-HSA-176187 | Activation of ATR in response to replication stress | 2.74E-02 | DBF4, RFC2, MCM10, MCM2, MCM6 |
| GO:0001527 | microfibril | 2.74E-02 | LTBP1, LTBP4, MFAP2, FBN2, MFAP1 |