Table 2.
Possible tegument proteins of EBV.
| EBV | alias name | HSV | HCMV | KSHV | Role in EBV lifecycle | Role in other herpesviruses |
|---|---|---|---|---|---|---|
| BALF1 | vBCL2 | (ORF16) | inhibit apoptosis [198] | viral gene expression, replication, progeny production, inhibit apoptosis in KSHV [200] | ||
| BALF2 | ssDNABP | UL29 | UL57 | ORF6 | essential for viral DNA synthesis, transcriptional activator [201,202] | essential for viral DNA synthesis [9] |
| BGLF3.5 | UL14 | ORF35 | no obvious function [188] | increase progeny production in HSV [16,190] | ||
| BMRF1 | EA-D | UL42 | UL44 | ORF59 | essential for viral DNA synthesis [201,205] | essential for viral DNA synthesis [9] |
| BORF2 | RR | UL39 | UL45 | ORF61 | increase progeny production [214], increase P53 [108], inhibit APOBEC3B [214,215], involved in nucleotide metabolism [9] | increase progeny production in non-dividing cells [218], involved in nucleotide metabolism, inhibit APOBEC3B in HSV [219] |
| BRLF1 | Rta | ORF50 | transcriptional activator [222], stabilize BORF1 [19] | transcriptional activator in KSHV [223] | ||
| BRRF2 | ORF48 | increase progeny production [224] | not reported | |||
| BXLF1 | TK | UL23 | ORF21 | no obvious function in cultured cell [211], nucleotide biosynthesis [210] | increase progeny production by improving infectivity in KSHV [213], nucleotide biosynthesis |
The numbers in the “Roles” column indicate reference numbers.