Table 2.
Summary of reported cases with anti-glomerular basement membrane disease and thrombotic microangiopathy
| References | Age Sex |
Authors’ institutions |
Coexisting conditions |
TMA on admission |
ADAMTS-13 activity |
CNS manifestations | Treatment | Hematologic outcome |
Renal outcome |
Survival outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| Li et al. 2004 [6] | 79 F | China | N/A | No | No data | No data | PE, CS, CY | No data | No data | Died |
| Stallworthy et al. 2006 [7] | 63 M | New Zealand | N/A | No | No data | No | PE | Improve | HD | Survived |
| Terryn et al. 2007 [8] | 37 M | Belgium | N/A | No | No data | Seizure | PE, CS, VCR | Improve | HD → KT | Survived |
| Kobayashi et al. 2009 [9] | 67 F | Japan | MPO-ANCA | No data | 48% | No data | CS, CY | No data | no data | Died |
| Gowrishankar et al. 2009 [10] | 38 M | India | N/A | Yes | No data | Headache | PE, CS | No data | HD | Survived |
| Watanabe et al. 2010 [11] | 61 F | Japan | MPO-ANCA | No | 35% | Brain infarction | PE, CS | No improve | HD | Died |
| Torok et al., 2010 [12] | 43 M | USA | N/A | Yes | 17% | Confusion | PE, CS, CY | Improve | no RRT | Survived |
| Miki et al. 2012 [13] | 68 M | Japan | HIT | No | 70% | No | PE, CS | Improve | HD | Survived |
| Cabrera et al. 2013 [14] | 27 M | Spain | N/A | No | < 1% | Seizure | PE, CS, CY | improve | HD | Survived |
| Momose et al. 2015 [15] | 54 M | Japan | Fibrillary GN | Yes | 32% | PRES, brain hemorrhage | PE, CS | Improve | HD | Survived |
| Manabe et al. 2017 [16] | 59 M | Japan | PR-3ANCA | Yes | 19.80% | Disturbed consciousness | PE, CS | No data | HD | Survived |
| Yu et al. 2017 [17] | 41 F | China | N/A | No | 74% | No | PE, CS | Improve | HD | Survived |
| Alirezaei et al. 2018 [18] | 25 M | Iran | N/A | No | 99.10% | Seizure | PE, CS, CY | Improve | HD | Survived |
| Malviya et al. 2021 [19] | 53 M | India | N/A | No | No data | Seizure | PE, CS, CY | Improve | HD | No data |
| Torigoe et al. 2021 [20] | 48 F | Japan | APS | No | No data | PRES | PE, CS, CY | No data | HD | Survived |
| Our case | 76 F | Japan | MPO-ANCA | No | 48% | Coma | PE, CS | No improve | HD | Died |
ADAMTS-13 a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13, APS antiphospholipid syndrome, CNS central nervous system, CS corticosteroid, CY cyclophosphamide, F female, Fibrillary GN Fibrillary glomerulonephritis, HD hemodialysis, KT kidney transplant, M male, MPO-ANCA myeloperoxidase-antineutrophil cytoplasmic antibody, N/A not applicable, PE plasma exchange, PR-3 ANCA proteinase 3 antineutrophil cytoplasmic antibody, PRES posterior reversible encephalopathy syndrome, RRT renal replacement therapy, TMA thrombotic microangiopathy, VCR vincristine