TABLE 5.
Effect of hypertensive disorders of pregnancy and all‐cause dementia taking into account potential mid‐life mediating factors assessed individually one at a time and then combined
|
Natural direct effect HR (95% CI) |
Natural indirect effect HR (95% CI) |
Total effect HR (95% CI) |
Proportion mediated | |
|---|---|---|---|---|
| Myocardial infarction | 1.40 (1.37, 1.43) | 1.09 (1.06, 1.12) | 1.53 (1.52, 1.54) | 22% |
| Ischemic heart disease | 1.40 (1.37, 1.44) | 1.08 (1.06, 1.11) | 1.52 (1.51, 1.53) | 19% |
| Heart failure | 1.38 (1.35, 1.42) | 1.07 (1.03, 1.10) | 1.47 (1.46, 1.48) | 17% |
| Stroke | 1.27 (1.25, 1.29) | 1.20 (1.18, 1.23) | 1.52 (1.52, 1.53) | 43% |
| Chronic kidney disease | 1.35 (1.32, 1.38) | 1.14 (1.11, 1.17) | 1.53 (1.52, 1.54) | 30% |
| Diabetes | 2.82 (0.83, 3.93) | 0.67 (0.43, 1.84) | 1.88 (1.51, 2.02) | NA |
| Hypertension | 1.21 (1.19, 1.24) | 1.14 (1.12, 1.17) | 1.39 (1.38. 1.40) | 41% |
| Anxiety | 1.38 (1.35, 1.41) | 1.10 (1.08, 1.13) | 1.52 (1.51, 1.53) | 23% |
| Depression | 1.49 (1.40, 1.57) | 1.02 (0.96, 1.08) | 1.51 (1.50, 1.52) | 4% |
| Overall | 1.12 (1.09, 1.15) | 1.19 (1.16, 1.22) | 1.33 (1.32, 1.34) | 61% |
Note: Adjusted for maternal age, birth year, and parity (1, 2, 3, 4, ≥5) at the time of the index pregnancy.
Abbreviations: CI, confidence interval; HR, hazard ratio.