Table 1.

Human IL-12 and DC signatures. List of genes used to define human IL-12 and DC (DC3, cCD1, cDC2 and pDC) signatures

IL-12 signature—derived from29	IFNG, GZMB, IL18RAP, ANXA3, IL12RB2, LAG3, GZMH, P2R×5, MAP3K8, FES, CXCL10, CXCL9, GZMK, IL18R1, LIF, FURIN, GTPBP8, METRNL, TBX21, NKG7, MTHFD2, ZBED2, BATF3, SLC7A5, SLC27A2, ATP2B4, BATF, GADD45G, SERPINB1, SATB1, NAMPT, UPP1, RGS16, ICOS, IRF8
DC3 signature— derived from12	GSTP1, IDO1, ATOX1, BIRC3, CCL19, CCR7, CD40, CD83, CDKN1A, CFLAR, CLIC2, CSF2RA, DAPP1, EEF1A1, EIF1, ERICH1, FNBP1, FSCN1, GPR157, GPX4, GRSF1, ID2, KIF2A, LAD1, LAMP3, LSP1, LY75, MARCKS, MARCKSL1, MGLL, MYL6, NFKB1, NUB1, POGLUT1, PTPN1, RAB8B, RAB9A, RASSF4, SYNGR2, TMEM176A, TMSB10, TNFAIP2, TRAF1, TUBB, TXN, VOPP1, ZFAS1
cDC1 signature—derived from12	ACTG1, FGL2, ACTB, ASAP1, BATF3, C1orf54, C20orf27, CADM1, CCND1, CD74, CLEC9A, CLNK, CPNE3, CPVL, CST3, CYB5R3, ENSA, HLA-DPA1, LGALS2, LSM6, NAAA, PPT1, RAB7B, RGS10, RPL8, S100A10, SNX3, TMEM14A, TMSB4X, VAC14, WDFY4, XCR1, GSTP1, IDO1
cDC2 signature—derived from12	ABI3, ACTR3, AIF1, ALDOA, ARHGDIB, ARPC3, ARPC5, C15orf48, CA2, CKLF, CLEC4A, FCGBP, GAPDH, GSN, LST1, LTB, PAK1, PKIB, PPM1N, RUNX3, S100B, SPI1, TPI1, VASP, ANXA5, CLEC10A, FCER1A
pDC signature—derived from12	IRF8, ALOX5AP, APP, BCL11A, C12orf75, CCDC50, CLIC3, CXCR3, CYB561A3, DERL3, ERP29, GPR183, GZMB, HERPUD1, HSP90B1, IL3RA, IRF4, IRF7, ITM2C, LILRA4, LILRB4, MAP1A, MPEG1, PARK7, PLAC8, PLD4, PLP2, PPP1R14B, RPS3A, RPS8, SEC61B, SEL1L3, SELL, SERPINF1, SLC15A4, SMPD3, SPCS1, SPIB, SRP14, TCF4, TPM2, TSPAN13, UGCG

cDC, conventional DC; DC, dendritic cell; IL, interleukin; pDC, plasmacytoid DC .