Table 2.

Evaluated add-back therapies with GnRHa for symptomatic endometriosis—adapted from Surrey (Table 1) (22)

Add-back regimen	6 mo only	<12 mo
Medroxyprogesterone acetate	+
Medrogesterone	+
Ethinyl estradiol + desogestrel	+
17β estradiol + MPA	+
CEE + MPA	+
NETA		+a
NETA + sodium etidronate		+
17β E2 + NETA		+
CEE + NETA		+
17β E2 + promegestrone		+
Tibolone		+

MPA = Medroxyprogesterone acetate, E2 = 17β estradiol, CEE = conjugated equine estrogens, NETA = Norethindrone acetate.

^aFDA approved for use in a 5 mg daily dose with depot leuprolide acetate for up to 1 year of therapy