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. 2023 May 22;68:101778. doi: 10.1016/j.smim.2023.101778

Table 1.

Definitions of Long COVID-19.

Name Symptoms/ clinical manifestation Time after COVID-19 COVID-19 severity Reference
Post COVID-19 condition/syndrome fatigue, shortness of breath, cognitive dysfunction or other symptoms affecting everyday functioning > 3 months, lasting at least 2 months mild-severe WHO, 2021 https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1
fatigue, exertion intolerance, partly meeting the criteria for ME/CFS 4–15 months mild-moderate [91]
fatigue, exertion intolerance, partly meeting the criteria for ME/CFS 7–19 months mild-moderate [86]
respiratory symptoms, pulmonary abnormalities 3–6 months severe [94]
Mainly cognitive and neurological symptoms > 3 months na [84]
Post-acute sequelae of COVID-19 (PASC) one or more of the following: constitutional, respiratory, cardiopulmonary, gastrointestinal, genitourinary, reologic, rash, musculoskeletal symptoms, trouble sleeping > 3 months mild-severe [78]
respiratory, gastrointestinal, neurological symptoms, anosmia/dysgeusia 2–3 months mild-severe [20]
pulmonary and extrapulmonary symptoms 2–3 months severe [96]
fatigue, respiratory, digestive, neurological, skin and mucous membrane, circulation symptoms > 1 months mild [76]
different symptoms including fatigue, dyspnea, respiratory, body aches > 1 months mainly mild-moderate [79]
respiratory symptoms, interstitial lung changes 3–12 months mild-severe [95]
pulmonary and extrapulmonary symptoms 2–3 months severe [96]
According to WHO case definition > 6 months mild-severe (mainly hospitalized) [97]
Long COVID fatigue, dyspena, chest pain > 4 months mild-severe [77]
breathing difficulties/breathlessness, fatigue/malaise, chest/throat pain, anxiety/depression, headache, myalgia, other pain, cognitive, abdominal symptoms 3–6 months mild-severe [71]
33 symptoms based on WHO case definition for post COVID-19 condition > 4 months mild [18]
with and without cognitive symptoms (e.g. "brain fog") na mainly mild [93]
Physical symptoms (e.g. arthralgia/myalgia, fatigue, cough), exertion intolerance 12 months severe [80]
e.g. fatigue, neurological, cardiopulmonary, gastrointestinal symptoms, trouble sleeping ∼4 months mild-severe Peluso et al., 2022
Fatigue, cough, shortness of breath 3–12 months mild-severe [85]
One or more symptoms of the following e.g. pulmonary, systemic, neurological or psychiatric symptoms 12 months mild and moderate/severe [83]
Post-acute COVID-19 syndrome different symptoms including fatigue, memory issues, loss of smell, abdominal pain ∼7 months mainly mild [81]