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. 2023 Apr 18;51(9):4637–4649. doi: 10.1093/nar/gkad278

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — The ‘open-closed’ asymmetric structure of EcTrpRS. (A) The domain organization of EcTrpRS. (B) The overall structure of homodimeric EcTrpRS in an asymmetric conformation with a molecule of the intermediate product TrpAMP bound at the active site cavity of the closed subunit (sub^Closed). EcTrpRS is presented as a cartoon model and colored according to (A), and TrpAMP is presented as a sphere. (C) Superposition of sub^Open and sub^Closed by aligning their ADs.