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. 2023 Apr 18;51(9):4126–4147. doi: 10.1093/nar/gkad268

Figure 6.

Figure 6.

Application of PN chemistry to stereorandom reference format-3 featuring reduced 2'-F content. (A) Schematic representation of Stereorandom reference format 3, designed based on (7). (B) Application of PN chemistry to reference format 3 in mice. Relative serum Ttr protein levels detected in mice treated with the indicated siRNA molecules. Data are presented as mean ± sem, n = 5 per group.