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. 2023 Apr 18;51(9):4126–4147. doi: 10.1093/nar/gkad268

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 9. — PN-based RNAi format has nominal impact on liver function or serum proteins in mice and is specific in primary hepatocytes. General design for siRNAs tested and dosing regimen for evaluation of liver function in wild-type mice. Graphs show liver enzyme function for alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), albumin and total serum proteins in CD-1 mice treated with the indicated siRNA or PBS. Each symbol represents one mouse and data are presented as mean ± sd, n = 5 per group.