TABLE 1.
Coefficient estimates and hazard ratio estimates of heart failure incidence equation
| Risk group | Variable | Hazard (95% CI) | Coefficiena (95% CI) |
|---|---|---|---|
| Socio-demographic | Age at T2DM diagnosed | ||
| 18–45 | |||
| 45–65 | 2.026 (1.460–2.810) | 0.706 (0.379–1.033) | |
| >65 | 4.940 (2.926–8.334) | 1.597 (1.074–2.120) | |
| College education | 0.520 (0.379–0.714) | −0.654 (−0.972–0.336) | |
| Metabolic syndrome | HbA1c (%) | 1.072 (0.953–1.205) | 0.069 (−0.049–9.187) |
| SBP (mmHg) | |||
| <120 | |||
| 120–140 | 1.139 (0.823–1.577) | 0.130 (−0.195–0.455) | |
| >140 | 1.751 (1.233–2.486) | 0.560 (0.209–0.911) | |
| BMI (kg/m2) | 1.045 (1.025–1.066) | 0.044 (0.024–0.064) | |
| HDL (mg/dl) | 0.978 (0.967–0.990) | −0.022 (−0.034–0.010) | |
| Diabetes complications | MI history | 1.677 (1.287–2.185) | 0.517 (0.252–0.782) |
| Revascularization history | 1.915 (1.482–2.476) | 0.650 (0.393–0.907) | |
| Cardiovascular medications | 1.758 (1.305–2.368) | 0.564 (0.266–0.862) | |
| Hypertension duration | 1.012 (1.002–1.022) | 0.012 (0.002–0.022) | |
| Nerve problems history | 1.452 (1.123–1.877) | 0.373 (0.116–0.630) | |
| Albuminuria history | 1.635 (1.290–2.073) | 0.492 (0.255–0.729) | |
| log(UACR) | 1.232 (1.155–1.315) | 0.209 (0.144–0.274) | |
| ESKD | 1.934 (1.118–3.349) | 0.015 (0.111–1.209) | |
| Health care utilization | Hospitalization this year ER room visit | 1.953 (1.304–2.923) | 0.669 (0.265–1.073) |
| 0 | |||
| 1 | 1.122 (0.720–1.747) | 0.115 (−0.328–0.558) | |
| ≥2 | 2.234 (1.246–4.007) | 0.804 (0.220–1.388) | |
| Log(scale) | 6.31 | ||
| Log(shape) | 0.567 | ||
| Brier score: training | 0.0064 | ||
| C-statistics: training | 0.838 (0.821–0.855) | ||
| Brier score: validation | 0.0060 | ||
| C-statistics: validation | 0.821 (0.775–0.866) | ||
| Event | 299 |
log(HR) = Coefficient.
exp(coefficient) = HR.
BMI, body mass index; ESKD, end stage kidney disease; Hb1Ac, glycated haemoglobin; HDL, high-density lipoproteins; HR, hazard ratio; MI, myocardial infarction; SBP, systolic blood pressure; T2DM, type 2 diabetes; UACR, urine albumin-to-creatinine ratio.