Skip to main content
. 2023 Apr 7;51(9):4191–4207. doi: 10.1093/nar/gkad265

Figure 5.

Figure 5.

Discussion supporting figure. (A, B) Intersection between the peaks identified in this study by MB-UV RIP-seq in HEK cells and editing sites identified by Sun et al. in HEK cells (54). Red and light-blue sections of doughnut plots display the portion of editing sites overlapping with RIP-seq peaks. (A, I) Overlap of ADAR1p150-specific editing sites and ADAR1p150-peaks. (II) Overlap of ADAR1p150-specific editing sites and ADAR1p110-peaks. (B, I) Overlap of editing sites targeted by both ADAR1 isoforms and ADAR1p150-peaks. (II) Overlap of sites edited by both ADAR1 isoforms and ADAR1p110-peaks. (C) Comparison of ADAR1-editome identified in MEFs and ADAR1p150-specific editing sites detected in the brain and the thymus of ADAR1p110−/− ADAR2−/−. (I) Editing sites identified as ADAR1p150-specific in the brain. (II) Editing sites identified as ADAR1p150-specific in the thymus. (D) ADAR1p150 and ADAR1p110-mediated editing ratios detected in MEFs for sites that overlap with ADAR1p150 sites in the brain identified by (Kim et al., 2021).