Table 1.

Counts of merged pG4-BS and pG4-CS uniquely mapping to different gene segments of protein coding genes in sense or anti-sense gene orientations

Region	Sense hits	Anti-sense hits	No. of gene symbols*	Proportion of genes	Ratio of gene proportions vs. pG4-CS
pG4-CS
Genic or promoter	40 899	35 512	14 462	0.76
Promoter	3504	3819	5089	0.27
Gene body	37 725	32 022	13 603	0.71
5′-UTR	941	1081	1758	0.09
3′-UTR	1585	1780	2483	0.13
Exons	671	1753	1720	0.09
Introns	25 656	20 438	10 526	0.55
pG4-BS
Genic or promoter	154 252	131 742	17 993	0.94	1.24
Promoter	9860	10 855	10 483	0.55	2.06
Gene body	145 291	121 918	17 498	0.91	1.29
5′-UTR	2555	2345	3763	0.20	2.14
3′-UTR	4865	6609	6021	0.31	2.42
Exons	2961	4994	4404	0.23	2.56
Introns	102 960	81 617	15 094	0.79	1.43
Regulatory pG4-BS**
Genic or promoter	102 831	88 778	17004	0.89	1.18
Promoter	8814	9723	9536	0.50	1.87
Gene body	94 835	79 991	16382	0.86	1.20
5′-UTR	2474	2279	3661	0.19	2.08
3′-UTR	3572	4867	4668	0.24	1.88
Exons	2156	3521	3368	0.18	1.96
Introns	63 835	50 731	13513	0.71	1.28

*Merged G4-BS which mapped to gene regulatory loci (DNAase hypersensitive regions and/or transcription factor binding sites).

**Human protein-coding genes (ENSEMBL 105).

Total number of annotated protein coding genes: n = 19 150.