Table 2.

Long-term symptoms.

Patients	Interfering drugs	Neurological	Cardiac and pulmonary	Digestive	Other	Kale’s score	CASS
1	No	Paraesthesia and numbness of hands and feet	Orthostatic intolerance, bradycardia, chest tightness, dyspnea	Constipation	Skin color changes, dysuria	13/16	0
2	No	Concentration and memory disorders, vertigo	Hyperventilation		Pain in all four limbs	15/16	0
3	No	Concentration disorders, tremor on standing, missing words	Tachycardia, palpitations			17/20	0
4	Propranolol, amitriptyline	Myalgia	Palpitations, dyspnea	Epigastric burning sensation	Chills	11/16	1
5	Paroxetine	Myalgia	Bradycardia, malaise			16/16	0
6	Codeine, bisoprolol	Paraesthesia, headache, hypoesthesia, balance disorder, concentration disorders	Chest pain, tachycardia	Alternating diarrhea and constipation	Hypoacousia	15/16	1
7	Midodrine, fluoxetine	Headache, tremor episodes, missing words, abnormal movements, concentration disorders	Orthostatic intolerance	Nausea	Tinnitus	12/16	0
8	No	Concentration disorders, vertigo, ataxia, swallowing difficulties	Chest tightness		Dysuria	15/16	0
9	No	Tremor (effort), weakness, dizziness, paraesthesia, concentration disorders	Orthostatic intolerance, dyspnea	Gastroparesis, constipation	Arthralgia, sicca syndrome, pollakiuria	12/16	0
10	Venlafaxine, nefopam, clobazam	Headache, myalgia, dizziness, concentration and sleeping disorders	Palpitations, chest pain, orthostatic intolerance, dyspnea, cough	Diarrhea	Diffuse pain	10/16	4
11	No	Tremor, headache, concentration disorders, myalgia	Orthostatic intolerance, dyspnea	Epigastric pain, alternating diarrhea and constipation, bloating	Sicca syndrome, urinary leakage	12/16	0
12	No	Concentration disorders, headache, vertigo,	Sinus tachycardia, dyspnea, cough	Epigastric pain, abdominal pain, bloating, alternating diarrhea and constipation	Alopecia, nasal congestion	6/16	1
13	Sotalol, tramadol, hydroxyzine	Dysphonia, paraesthesia, headache, concentration disorders	Tachycardia	Abdominal pain, postprandrial bloating, nausea/vomiting after effort	Itching, eczema	7/16	3
14	Famotidine, ebastine	headache, paraesthesia,	Postural tachycardia, palpitations, dyspnea, postprandrial malaise	Abdominal cramps		12/16	1
15	Duloxetine, amitriptyline, nefopam, famotidine	Headache, concentration disorders, irritability, hypersomnia (17 h/day)	Chest pain, dyspnea (at effort)	Diarrhea, postprandrial abdominal pain, anorexia, constipation	Blurred vision, alopecia, urticaria	10/16	0
16	No	Vertigo, insomnia, abnormal movements of left hemibody	Positional and postprandrial malaise, tachycardia, sensation of chest tightness	Vomiting, abdominal pain, dyspeptic syndrome with early satiety	Hypersudation, sicca syndrome, frostbite	12/16	0

Kale’s score ranges from 0 (severely disabled) to 20 (male) or 16 (female) in normal subjects. CASS, Composite Autonomic Severity Score.