Figure 6.

Solution conditions alter IDR entropic force. (A) End-to-end distance for UGDH-fl as a function of backbone:solution interactions. The blow-up ensembles show representative conformations in attractive, neutral (aqueous), and repulsive solutions. (B) Box plot showing the change in entropic force due to change in protein backbone:solvent interactions. Boxes show the median as a central line, the median 50% as the box limits, and the median 90% of the data as the whiskers. Individual sequences are shown as points overlaid on each box. (C) Solution sensitivity of three IDR ensembles. Solution sensitivity is quantified using relative R_ee compared to the R_ee of the same IDR in the neutral (aqueous) solution. (D) Change in entropic force due to solution condition changes for the three IDR ensembles.