Table 1.
The regulatory factors of SCP-2.
| Regulators | Cells/Tissues | Mechanisms | Functions | Ref. |
|---|---|---|---|---|
| Stimulators | ||||
| FOXO3a | Human colon carcinoma cells | Binds SCP-2 promoter region | Protects against H2O2/Cu2+-induced oxidative damage | 48 |
| SF-1 | Luteal cells | Binds SCP-2 promoter region | Promotes steroid hormone production | 49 |
| HR-3 | Aag-2 cells | Binds SCP-2 promoter region | Promotes sterol trafficking | 50 |
| cAMP | Grs-21 cells, Immature female Sprague–Dawley rats | SF-1 | Promotes steroid hormone production | 51 |
| Inhibitors | ||||
| ATF-2 | Aedes aegypti | Binds SCP-2 promoter region | Plays a negative role in development and growth | 52 |
| THAP | Aedes aegypti | Binds SCP-2 promoter region | Plays a negative role in development and growth | 52 |
| miR-15a | DF1 cells, Chicken breast muscle tissue | Targets the 3′UTR of SCP-2 mRNA | Promotes the differentiation of intramuscular preadipocytes | 53 |
| miR-1285-5p | Type 2 diabetes mellitus clinical samples | Promotes the hypermethylation of SCP-2 promoter region | A promising biomarkers and therapeutic target for type 2 diabetes mellitus | 54 |
| Gemfibrozil | Male Sprague–Dawley rats | Unknown | Plays a hypolipidemic role | 55 |