TABLE 3.
Comparison of potency ratios of mitragynine, morphine, or 7HMG in the presence of ketoconazole pretreated to produce the discriminative stimulus, rate-decreasing, and antinociceptive effects in mitragynine- or morphine-trained rats relative to the corresponding compounds alone
Each value (95% CIs in parentheses) is for a combination of females with males unless described and calculated as a division of the ED50 values of mitragynine, morphine, or 7HMG in the presence of ketoconazole (56 mg/kg, o.g., 30 minutes prior to sessions) pretreated from those of the corresponding compounds alone, as shown in Table 2. The sample sizes are described in each figure legend (Figs. 3 and 4). Significant differences are italicized.
| Rats Trained with Mitragynine | |||
|---|---|---|---|
| Test Compound | Discriminative Stimulus | Response Rate | Antinociception |
| 56 mg/kg Ketoconazole + Mitragynine vs. Mitragynine Alone | 4.24 (2.52, 6.78) | 1.21 (0.746, 2.03) | Not Applicable |
| Rats Trained with Morphine | |||
| Test compound | Discriminative Stimulus | Response Rate | Antinociception |
| 56 mg/kg Ketoconazole + Morphine vs. Morphine Alone | 0.621 (0.321, 1.08) | 0.858 (0.575, 1.26) | 1.07 (0.858, 1.33) |
| 56 mg/kg Ketoconazole + Mitragynine vs. Mitragynine Alone | 4.69 (2.16, 14.2) | 1.38 (0.883, 2.34) | Not Applicable |
| 56 mg/kg Ketoconazole + 7HMG vs. 7HMG Alone | 9.65 (2.22, 18.3) | 2.57 (1.43, 4.32) | 4.10 (2.94, 5.76) |