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. 2022 May 26;10(2):505–520. doi: 10.1016/j.gendis.2022.05.008

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© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — The prospective role of m6A modification in the pathogenesis of PVR. Retinal trauma induces the synthesis and secretion of TGF-β. TGF-β promotes the pathogenesis of PVR through the following pathways:1. activating snail through the Smad 2/3 pathways; 2. increasing FTO expression; 3. downregulating the expression of METTL3 (the negative regulator of EMT and fibrosis), which results in the repression of epithelial marker genes (E-cadherin and ZO-1) expression but enhances the mesenchymal gene (αSMA, FN, vimentin) expression and mesenchymal phenotype.