Table 2.
Correlation of cortical thickness signature with clinical parameters in derivation samples of age-matched DLB and healthy controls
| DLB-pattern | AD-pattern | Mean cortical thickness | ||||
|---|---|---|---|---|---|---|
| Correlation coefficient | P value | Correlation coefficient | P value | Correlation coefficient | P value | |
| MMSE | − 0.31 | 0.035 | − 0.088 | 0.55 | 0.37 | 0.011 |
| Cognition (MDS-UPDRS part I) | 0.051 | 0.79 | 0.17 | 0.41 | − 0.64 | 4.18 × 10–4 |
| MDS-UPDRS part I | − 0.042 | 0.92 | 0.12 | 0.52 | − 0.45 | 0.017 |
| MDS-UPDRS part II | 0.041 | 0.90 | − 0.16 | 0.42 | − 0.52 | 0.0045 |
| MDS-UPDRS part III | 0.051 | 0.87 | 0.24 | 0.26 | − 0.58 | 0.0029 |
| Digit span test | − 0.11 | 0.58 | 0.22 | 0.28 | 0.053 | 0.80 |
| TMT-A | − 0.55 | 0.024 | − 0.081 | 0.79 | 0.058 | 0.84 |
| CWST | − 0.24 | 0.32 | − 0.26 | 0.35 | − 0.11 | 0.69 |
| BNT | − 0.35 | 0.062 | − 0.095 | 0.65 | 0.48 | 0.013 |
| RCFT | − 0.54 | 0.0047 | − 0.19 | 0.38 | 0.33 | 0.12 |
| SVLTi | − 0.11 | 0.56 | − 0.065 | 0.75 | 0.37 | 0.060 |
| SVLTd | − 0.25 | 0.18 | − 0.089 | 0.66 | 0.32 | 0.10 |
| SVLTr | − 0.16 | 0.41 | 0.14 | 0.49 | 0.50 | 0.0078 |
| COWAT | 0.083 | 0.73 | 0.38 | 0.16 | − 0.028 | 0.92 |
| TMT-B | − 0.56 | 0.036 | − 0.29 | 0.33 | 0.24 | 0.41 |
Age and sex were included as cofactors for correlation analysis between cortical thickness pattern score and clinical variables MDS-UPDRS part I (except for cognition subscore), II and III. Age, sex and education year were included as cofactors in the correlation analysis between cortical thickness patterns and cognitive profiles (Cognition subscore from MDS-UPDRS part I and scores from neuropsychological tests)
The significant values (P < 0.05) are shown in bold
BNT Boston Naming Test, COWAT Controlled Oral Word Association Test, CWST Korean Color Word Stroop Test, DLB Dementia with Lewy bodies, MDS-UPDRS Movement Disorders Society-Unified Parkinson Disease Rating Scale, RCFT Rey Complex Figure Test copy, SVLT Seoul Verbal Learning Test, TMT Trail Making Test