Table 1.
Clinico-radiological and pathological features of the patients with BCBM
| Variable | No. | Percent | |
|---|---|---|---|
| Age (year) | < 60 | 35 | 70% |
| ≥ 60 | 15 | 30% | |
| Sex | Female | 49 | 98% |
| Male | 1 | 2% | |
| Molecular type | Luminal A | 10 | 20% |
| Luminal B | 6 | 12% | |
| HER2 | 19 | 38% | |
| TN | 15 | 30% | |
| CAF pattern | Type A | 24 | 48% |
| Type B | 20 | 40% | |
| Type C | 6 | 12% | |
| PDGFR-β | Low | 27 | 54% |
| High | 23 | 46% | |
| α-SMA | Low | 27 | 54% |
| High | 23 | 46% | |
| Tumor location | Supratentorial | 37 | 74% |
| Infratentorial | 13 | 26% | |
| Extracranial Mets | Absent | 12 | 24% |
| Present | 38 | 76% | |
| BM symptom | Mild to moderate | 31 | 62% |
| Severe | 19 | 38% | |
| KPS | ≥ 80 | 32 | 64% |
| < 80 | 18 | 36% | |
| BM multiplicity | Single | 24 | 48% |
| Multiple | 26 | 52% | |
| BM development | Metachronous | 49 | 98% |
| Synchronous | 1 | 2% | |
| BM size | < 4 cm | 22 | 44% |
| ≥ 4 cm | 28 | 56% | |
| Peritumoral edema | Mild to moderate | 27 | 54% |
| Severe | 23 | 46% | |
| Tumor nature | Solid | 27 | 54% |
| Cystic or mixed | 23 | 46% | |
| Resection degree | Gross total | 38 | 76% |
| Partial to subtotal | 12 | 24% | |
| Postoperative RT/GKS | Absent | 16 | 32% |
| Present | 34 | 68% | |
BC, breast cancer; BM, brain metastasis; α-SMA, alpha-smooth muscle actin; CAF, cancer-associated fibroblast; GKS, gamma knife radiosurgery; KPS, Karnofsky performance score; Mets, metastasis; PDGFR-β, platelet-derived growth factor receptor-beta; RT, radiation treatment; TN, triple negative