Table 2.
Structures and biological activity data of compounds 9–22.
| Drug | Structure | Class | IC50a (μM) |
|---|---|---|---|
| N3 (9) |  |
Mpro inhibitor | – |
| Disulfiram (10) |  |
Alcohol deterrent | 9.35 |
| Carmofur (11) |  |
Antineoplastic agent | 1.82 |
| Shikonin (12) |  |
Pyruvate kinase M2 inhibitor | 15.75 |
| Tideglusib (13) |  |
Anti-inflammatory and neuroprotective agents | 1.55 |
| PX-12 (14) |  |
Thioredoxin-1 inhibitor | 21.39 |
| TDZD-8 (15) |  |
GSK-3β inhibitor | 2.15 |
| Boceprevir (16) |  |
Hepatitis C virus NS3/4A protease inhibitor | 4.13 |
| GC-376 (17) |  |
Mpro inhibitor | 0.03 |
| MG-132 (18) |  |
Proteasome inhibitor | 3.90 |
| 19 |  |
Calpain inhibitors II | 0.97 |
| 20 |  |
Calpain inhibitors XII | 0.45 |
| YH-53 (21) |  |
SARS-CoV-1 Mpro inhibitor |
– |
| Teicoplanin (22) |  |
Glycopeptide antibiotic | 1.50 |
a
SARS-CoV-2 Mpro IC50.