Table 3.
Structures and biological activity data of compounds 23–39.
| Drug | Structure | Class | IC50a (μM) |
|---|---|---|---|
| Hydroxycobalamin (23) |  |
Vitamin B12a | 3.29 |
| Walrycin B (24) |  |
Antibacterial agent | 0.26 |
| Z-DEVD-FMK （25） |
 |
Caspase-3 inhibitor | 6.81 |
| LLL-12 (26) |  |
Signal transducer and activator of transcriptionl 3 inhibitor | 9.48 |
| Suramin sodium (27) |  |
Antiprotozoal drug | 6.5 |
| Z-FA-FMK (28) |  |
Cysteine protease inhibitor | 11.39 |
| Ethacrynic acid (29) |  |
Diuretic | 1.11 |
| Naproxen (30) |  |
Anti-inflammatory drug | 3.45 |
| Allopurinol (31) |  |
Xanthine oxidase inhibitor | 3.77 |
| Butenafine hydrochloride (32) |  |
Antifungal | 5.40 |
| Raloxifene hydrochloride (33) |  |
Estrogen receptor modulator | 5.61 |
| Tranylcypromine hydrochloride (34) |  |
Antidepressant drug | 8.64 |
| Saquinavir mesylate (35) |  |
HIV protease inhibitor | 9.92 |
| JCP400 (36) |  |
cysteine proteases inhibitor | 1.74 |
| JCP403 (37) |  |
cysteine proteases inhibitor | 2.99 |
| JCP474 (38) |  |
cysteine proteases inhibitor | 0.96 |
| JCP543 (39) |  |
cysteine proteases inhibitor | 0.49 |
a
SARS-CoV-2 Mpro IC50.