Table 4.
Structures and biological activity data of compounds 40–54.
| Drug | Structure | Class | IC50a (μM) |
|---|---|---|---|
| Thiomersal (40) |  |
antiseptic and antifungal agent | 0.60 |
| Phenylmercury acetate (41) |  |
fungicide and slimicide | 0.40 |
| 42 |  |
10.60 | |
| Evans blue (43) |  |
l-glutamate uptake inhibitor | 0.20 |
| 44 |  |
SARS-CoV-1 Mpro inhibitor |
0.15 |
| MAC-5576 (45) |  |
Mpro inhibitor | 0.08 |
| Baicalein (46) |  |
Xanthine oxidase inhibitor | 0.39 |
| Scutellarein (47) |  |
Anti-inflammatory | 5.80 |
| Dihydromyricetin (48) |  |
Dihydropyrimidinase inhibitor | 1.20 |
| Quercetagetin (49) |  |
Pim-1 kinase inhibitor | 1.24 |
| Myricetin (50) |  |
Antioxidant | 2.86 |
| Acriflavine (51) |  |
Antibacterial agent | 5.60 |
| Proflavine Hemisulfate (52) |  |
Antibacterial agent | 2.07 |
| 53 |  |
Metallo-β-lactamase inhibitor | 0.07 |
| 54 |  |
Metallo-β-lactamase inhibitor | 0.11 |
a
SARS-CoV-2 Mpro IC50.