Table 2.
Characteristics of patients with COVID-19 or SARS-CoV-2 vaccination associated TMA
TMA diagnosis |
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Patien number | Sex | Age | Event | Time to TMA from eventb | Native kidney; kindey graft | SCr | PLT | LDH | UPCR | Kidneybiopsy | TMA treatment | Outcome3 mo |
7a | M | 34 | COV | 44 | G | 6.28 | 207 | 252 | 4746 | active TMA | 5× PLEX | SCr 6.78 |
9a | F | 32 | COV | 28 | G | 1.54 | 355 | 203 | 3425 | TMA vs. ABMR | on antiC5 | SCr 1.66 |
24a | F | 21 | COV | 16 | N | 18.96 | 124 | 422 | n.a. | n.a. | anti C5 | chronic HD |
27a | M | 67 | VAC | 10 | G | 2.54 | 132 | 277 | 3246 | relapsing TMA | antiC5 | SCr 2.63 |
ABMR, antibody mediated rejection; anti C5, eculizumab or ravulizumab therapy; CFH, complement factor H; COV, coronavirus disease 19; F, female; G, kidney graft; HD, hemodialysis; LDH, lactate dehydrogenase (reference range: <250 U/l); M, male; N, native kidney; n.a., not available; PLEX, plasma exchange; PLT, platelet count (reference range: 150-350 G/L); SCr, serum creatinine in mg/dl; TMA, thrombotic microangiopathy; UPCR, urinary protein to creatinine ratio (reference range: <200 mg/g); VAC, SARS-CoV-2 vaccination.
TMA relapse.
In days.