TABLE 4.
Summary statistics for covariates measured on newly diagnosed diabetic patients receiving care in the VA healthcare system stratified by years (2004–2009 and 2010–2014) and monotherapy type (Metformin or Sulfonylurea). The standardized absolute mean differences is an average measurement between the four temporal and treatment defined groups.
| Metformin (2004–2009) | Metformin (2010–2014) | Sulfonylurea (2004–2009) | Sulfonylurea (2010–2014) | Standardized Absolute Mean Difference | |
|---|---|---|---|---|---|
|
| |||||
| Patient Count | 84003 | 100612 | 29447 | 11736 | - |
| Baseline Age | 61.90 (11.64) | 60.45 (11.50) | 67.32 (12.47) | 66.95 (12.72) | 0.354 |
| Male | 80964 (96.4) | 95906 (95.3) | 28912(98.2) | 11472 (97.8) | 0.095 |
| Race/Ethnicity | 0.185 | ||||
| Non-hispanic White | 11927 (14.2) | 20132 (20.0) | 4038 (13.7) | 2253 (19.2) | |
| Non-hispanic Black | 4730 (5.6) | 6810(6.8) | 1517 (5.2) | 614 (5.2) | |
| Hispanic | 10897 (13.0) | 8583 (8.5) | 5073 (17.2) | 1123 (9.6) | |
| Other | 56449 (67.2) | 65087 (64.7) | 18819 (63.9) | 7746 (66.0) | |
| Smoking Status | 0.127 | ||||
| Current | 21475 (25.6) | 30603 (30.4) | 6365 (21.6) | 2925 (24.9) | |
| Former | 42751 (50.9) | 44354 (44.1) | 16396 (55.7) | 5935 (50.6) | |
| Never | 19777 (23.5) | 25655 (25.5) | 6686 (22.7) | 2876 (24.5) | |
| BMI | 32.96 (6.43) | 33.66 (6.52) | 31.20 (6.00) | 32.08 (6.22) | 0.220 |
| SBP | 133.03 (16.61) | 132.35 (15.93) | 133.83 (18.37) | 131.80(17.31) | 0.066 |
| DBP | 76.83 (10.82) | 78.69 (10.76) | 74.90 (11.59) | 75.81 (11.45) | 0.185 |
| HDL | 39.19 (10.76) | 40.14 (10.97) | 39.23 (11.51) | 39.60(11.50) | 0.048 |
| LDL | 103.43 (34.93) | 102.68 (35.30) | 101.32 (35.46) | 96.99 (35.06) | 0.098 |
| Total Cholesterol | 179.60(44.15) | 178.57 (44.51) | 177.91 (46.41) | 173.49 (46.68) | 0.069 |
| Triglycerides | 205.36 (192.15) | 203.67 (198.23) | 206.01 (198.88) | 208.68 (216.49) | 0.013 |
| Fasting Plasma Glucose | 151.54 (62.26) | 149.71 (63.64) | 165.87 (80.76) | 163.67 (78.23) | 0.141 |
| HbA1c | 7.17 (1.43) | 7.28 (1.41) | 7.42 (1.63) | 7.54 (1.54) | 0.139 |
| Estimated GFR | 78.41 (18.59) | 83.88 (20.08) | 66.83 (22.97) | 66.15 (24.76) | 0.500 |
| Creatinine | 1.03 (0.20) | 0.98 (0.20) | 1.25 (0.48) | 1.29 (0.56) | 0.493 |
| History of CAD | 31211 (37.2) | 25771 (25.6) | 14071 (47.8) | 4535 (38.6) | 0.240 |
| History of CHF | 8768 (10.4) | 6086 (6.0) | 5916 (20.1) | 1752(14.9) | 0.237 |
| History of Stroke | 10572(12.6) | 8385 (8.3) | 5230 (17.8) | 1645 (14.0) | 0.149 |
| History of Kidney Disease | 571 (0.7) | 237 (0.2) | 1214 (4.1) | 316(2.7) | 0.167 |
| History of Liver Disease | 424 (0.5) | 349 (0.3) | 278 (0.9) | 86 (0.7) | 0.043 |