Table 2.

Cyclic Carboxylic Acid Scope for the β,γ-Dehydrogenation and Vinyl C─H Olefination of Free Carboxylic Acids^a,b

^aConditions: 1 (0.1 mmol), benzyl acrylate 2a (0.2 mmol), Pd(OAc)₂ (10 mol%), L9 (13 mol%), KF (2.0 equiv), Ag₂CO₃ (2.0 equiv), HFIP/MeCN (1.0 mL/0.1 mL), 100 °C, 24 h.

^bIsolated yields. The dr values were determined by ¹H NMR analysis of the crude product.

^cLiF (1.0 equiv) and HFIP/MeCN (1.0 mL/0.15 mL) were used.

^dL15 was used instead of L9.

^eL6 was used instead of L9.

^fThe reaction was run on a 1.0 mmol scale.