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. Author manuscript; available in PMC: 2023 Jul 20.
Published in final edited form as: J Am Chem Soc. 2022 Jul 8;144(28):12924–12933. doi: 10.1021/jacs.2c04779

Table 3.

Acyclic Carboxylic Acid Scope for the β,γ-Dehydrogenation and Vinyl C─H Olefination of Free Carboxylic Acidsa,b

graphic file with name nihms-1896983-t0009.jpg
a

Conditions: 1 (0.1 mmol), benzyl acrylate 2a (0.2 mmol), Pd(OAc)2 (10 mol%), L9 (13 mol%), NaOAc (2.0 equiv), Ag2CO3 (2.0 equiv), HFIP/MeCN (0.95 mL/0.05 mL), 100 °C, 16 h.

b

Isolated yields. The dr values were determined by 1H NMR analysis of the crude product.

c

L15 was used instead of L9.

d

Pd(OAc)2 (15 mol%) and L9 (16 mol%) were used.

e

L6 was used instead of L9.

f

The reaction was run on a 1.0 mmol scale.