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. 2022 Nov 9;227(8):939–950. doi: 10.1093/infdis/jiac445

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© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Vector immunity prevaccination and vaccine-induced immune response. The baseline Ad26 neutralization titers of participants in the United States and East Africa (A), and the Ad26 neutralization titers of participants in the bivalent group prior to each vaccination (B) were measured. Correlation analysis was performed in the population described in (A) to assess the association between Ad26 neutralization titers prevaccination and the corresponding IgG response against clade C postvaccination among participants receiving the regimen with the bivalent protein vaccine in the United States (C) and East Africa (D). A, Individual data, geometric mean, and 95% confidence interval are presented. C and D, line represents the Pearson correlation and the shaded areas indicate the 95% confidence interval. *P < .05, Pearson statistical test. Abbreviations: ELISA, enzyme-linked immunosorbent assay; GM, geometric mean; IC_90, 90% inhibitory concentration; IgG, immunoglobulin G; LLOQ, lower limit of quantification; Serop. %, percentage seropositive; VNA, virus neutralization assay.