Table 3.

Influence of Lumefantrine Plasma Concentration Below Cut-off Values on Treatment Outcome in SSA Populations

Study	Country	Study Population	Plasma Concentration/Cut-Off Values	Study End Points	Treatment Outcome (study end points)	Reference
Kilonzi et al	Tanzania	Children	200ng/µL	ACPR	Was not different between those with low and above cut-off values	[56]
Bell et al	Malawi		175ng/µL	ACPR	Was not different between those with low and above cut-off values	[57]
Marwa et al	Tanzania	Children and adults	175&200ng/µL	ACPR	Was not different between those with low and above cut-off values	[58]
Checchi et al	Uganda	Children and adults	280ng/µL	Recrudescence	Was not different between those with low and above cut-off values	[59]
Ippolito et al	Zambia	Children	280ng/µL	Re-infection	No difference between patients with low and above cut-off values	[60]