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. Author manuscript; available in PMC: 2023 May 22.
Published in final edited form as: Trends Cell Biol. 2022 Feb 7;32(4):338–350. doi: 10.1016/j.tcb.2022.01.004

Figure 3. Classical and alternative nonhomologous end-joining (NHEJ) pathways.

Figure 3.

After the formation of a double-strand break, the classical (left) or the alternative (right) nonhomologous end-joining pathways repair DNA damage through break recognition, end binding/synapsis, end processing, and final ligation of DNA. Proteins marked with a yellow star have been shown to have decreased expression during aging.