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. 2023 May 9;6:0126. doi: 10.34133/research.0126

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Copyright © 2023 Ding Ding et al.

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Fig. 1. — Radiolabeling of the SGC8 aptamer and targeting functionality investigation. (A) Schematic illustration of SGC8 aptamer radiolabeling. (B) Flow cytometry study of the SGC8 aptamer and NOTA-modified SGC8 aptamer specific binding on PTK-7-overexpressed cells. (C) Binding affinity study against target cells of NOTA-SGC8 and SGC8. K_d values are 3.49 nM and 1.88 nM, respectively. (D) Cell binding assay of radiolabeled aptamer ⁶⁸Ga[Ga]-NOTA-SGC8 and ⁶⁸Ga[Ga]-NOTA-Library, ***P ≤ 0.001. These results demonstrated that the SGC8 aptamer maintained its targeting functionality after NOTA modification and ⁶⁸Ga radioisotope labeling.