Table.

Summary of aptamer’s preclinical toxicity evaluation.

Single-dose toxicity test
Dosage	Clinical observation	Body weights	Hematology	Bone marrow micronucleus test
40 mg/kg	Normal	Normal	Normal	Normal
80 mg/kg	Normal	Normal	Normal	Abnormal
*Normal/abnormal: Without/with statistical differences compared with the saline group
Mutagenic, carcinogenic, and genotoxicity test
Salmonella typhimurium reverse mutation assay				Negative
Chromosomal aberration test in mammalian cells				Negative